AGE, HYPERTENSION AND ARTERIAL FUNCTION
نویسندگان
چکیده
منابع مشابه
Modern age pathology of pulmonary arterial hypertension.
RATIONALE The impact of modern treatments of pulmonary arterial hypertension (PAH) on pulmonary vascular pathology remains unknown. OBJECTIVES To assess the spectrum of pulmonary vascular remodeling in the modern era of PAH medication. METHODS Assessment of pulmonary vascular remodeling and inflammation in 62 PAH and 28 control explanted lungs systematically sampled. MEASUREMENTS AND MAIN...
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BACKGROUND Elevated right atrial (RA) pressure is an established prognostic measure in pulmonary arterial hypertension (PAH). However, little is known about perturbations in RA function in PAH. METHODS AND RESULTS Reservoir (RA longitudinal strain [RA LS]), conduit (RA early LS rate), and active (RA late LS rate) phases were assessed by 2D speckle tracking in 65 patients with PAH, 6-minute wa...
متن کاملRegulation and function of miR-214 in pulmonary arterial hypertension.
Dysregulation of microRNAs (miRNAs) can contribute to the etiology of diseases, including pulmonary arterial hypertension (PAH). Here we investigated a potential role for the miR-214 stem loop miRNA and the closely linked miR-199a miRNAs in PAH. All 4 miRNAs were upregulated in the lung and right ventricle (RV) in mice and rats exposed to the Sugen (SU) 5416 hypoxia model of PAH. Further, expre...
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Development (CNPq; Brasilia, Brazil; #474621/2004-9), Rio de Janeiro Research Foundation (FAPERJ; Rio de Janeiro, Brazil; #E-26/100.461/2007), and, in part, by the Zerbini Foundation (São Paulo, Brazil). L.M. Ueno was supported by FAPESP as a post-doctoral fellow (#03/10881-2); and C.E. Negrao, M.U.P.B. Rondon and A.C.L. Nobrega were supported by CNPq (#302146/2007-5, #303518/2008-1 and #301168...
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ژورنال
عنوان ژورنال: Clinical and Experimental Pharmacology and Physiology
سال: 2007
ISSN: 0305-1870,1440-1681
DOI: 10.1111/j.1440-1681.2007.04657.x